The Anti-Cadherin-13 (CDH13) Antibody (CAB3244) is an essential tool for researchers studying the CDH13 protein, a crucial cell adhesion molecule involved in various cellular processes. This polyclonal antibody, generated in rabbits, exhibits high reactivity and specificity with human samples, making it an ideal choice for a wide range of research applications.CDH13, also known as T-cadherin, plays a vital role in mediating cell-cell adhesion and signaling pathways, impacting cell migration, proliferation, and differentiation. Dysregulation of CDH13 has been implicated in various diseases, including cancer, cardiovascular disorders, and neurological conditions, underscoring its importance as a therapeutic target.
The Anti-Cadherin-13 Antibody enables researchers to detect and analyze CDH13 expression in different cell types and tissues, facilitating studies in developmental biology, cancer biology, and neurobiology. By understanding the functions and regulation of CDH13, researchers can gain valuable insights into disease mechanisms and potentially identify novel therapeutic strategies.
Product Name:
Cadherin-13 (CDH13) Rabbit Monoclonal Antibody
SKU:
CAB3244
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 101-200 of human Cadherin-13 (CDH13) (P55290).
This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
1012
Clone Number:
ARC1931
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse heart, using Cadherin-13 (CDH13) Rabbit mAb (CAB3244) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
