E-Cadherin Rabbit Polyclonal Antibody (CAB11492)
- SKU:
- CAB11492
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | E-Cadherin Rabbit Polyclonal Antibody |
SKU: | CAB11492 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 373-622 of human E-Cadherin (NP_004351.1). |
Sequence: | PIFN PTTY KGQV PENE ANVV ITTL KVTD ADAP NTPA WEAV YTIL NDDG GQFV VTTN PVNN DGIL KTAK GLDF EAKQ QYIL HVAV TNVV PFEV SLTT STAT VTVD VLDV NEAP IFVP PEKR VEVS EDFG VGQE ITSY TAQE PDTF MEQK ITYR IWRD TANW LEIN PDTG AIST RAEL DRED FEHV KNST YTAL IIAT DNGS PVAT GTGT LLLI LSDV NDNA PIPE PRTI FFCE RNPK PQVI NIID ADLP PN |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:50 - 1:100 IF/ICC,1:50 - 1:200 |
Synonyms: | UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324; E-Cadherin |
Positive Sample: | HCT116,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Endosome, Golgi apparatus, Single-pass type I membrane protein, trans-Golgi network. |
Calculated MW: | 97kDa |
Observed MW: | 125kDa/135kDa |
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
Purification Method: | Affinity purification |
Gene ID: | 999 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |