CAD Rabbit Polyclonal Antibody (CAB8344)
- SKU:
- CAB8344
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | CAD Rabbit Polyclonal Antibody |
SKU: | CAB8344 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1650-1900 of human CAD (NP_004332.2). |
Sequence: | LERL GPGK GEVR PELG SRQD VEAL WENM AVID CFAS DHAP HTLE EKCG SRPP PGFP GLET MLPL LLTA VSEG RLSL DDLL QRLH HNPR RIFH LPPQ EDTY VEVD LEHE WTIP SHMP FSKA HWTP FEGQ KVKG TVRR VVLR GEVA YIDG QVLV PPGY GQDV RKWP QGAV PQLP PSAP ATSE MTTT PERP RRGI PGLP DGRF HLPP RIHR ASDP GLPA EEPK EKSS RKVA EPEL MGTP DGTC YPPP PVPR QAS |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 IF/ICC,1:50 - 1:200 |
Synonyms: | CDG1Z; DEE50; GATD4; EIEE50; CAD |
Positive Sample: | SW620,HepG2,HeLa,HL-60 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 243kDa |
Observed MW: | 243kDa |
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 790 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |