UniProt Protein Function: | CACTIN: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing. Belongs to the CACTIN family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Spliceosome; RNA splicingChromosomal Location of Human Ortholog: 19p13.3Cellular Component: nucleoplasm; cytoplasm; nucleusMolecular Function: protein bindingBiological Process: nuclear mRNA splicing, via spliceosome; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of protein amino acid phosphorylation; inhibition of NF-kappaB transcription factor; multicellular organismal development; negative regulation of toll-like receptor signaling pathway; negative regulation of interleukin-8 production; innate immune response; negative regulation of tumor necrosis factor production; negative regulation of interferon-beta production |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q8WUQ7 |
NCBI GenInfo Identifier: | 122937392 |
NCBI Gene ID: | 58509 |
NCBI Accession: | NP_001074012.1 |
UniProt Secondary Accession: | Q8WUQ7 |
UniProt Related Accession: | Q8WUQ7 |
Molecular Weight: | 89 kDa |
NCBI Full Name: | cactin |
NCBI Synonym Full Names: | cactin, spliceosome C complex subunit |
NCBI Official Symbol: | CACTINÂ Â |
NCBI Official Synonym Symbols: | fSAPc; C19orf29; NY-REN-24Â Â |
NCBI Protein Information: | cactin |
UniProt Protein Name: | Cactin |
UniProt Synonym Protein Names: | Renal carcinoma antigen NY-REN-24 |
Protein Family: | Cactin |
UniProt Gene Name: | CACTINÂ Â |
UniProt Entry Name: | CATIN_HUMAN |