The CACTIN Antibody (PACO07291) is a highly specific antibody designed for research involving CACTIN, a protein involved in a variety of cellular processes including gene expression regulation, DNA repair, and cell cycle progression. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in applications such as immunofluorescence and immunohistochemistry.CACTIN, a multifunctional protein that interacts with various transcription factors and chromatin-modifying proteins, plays a crucial role in maintaining genomic stability and regulating gene expression.
Its involvement in these key cellular processes makes it a promising target for research in fields such as molecular biology, cancer biology, and developmental biology.The CACTIN Antibody allows for the detection and analysis of CACTIN protein levels in different cell types and tissues, providing valuable insights into its functional roles and potential implications in disease development. Researchers studying gene regulation, DNA repair mechanisms, and cell cycle control will find this antibody to be a valuable tool in their investigations.
Antibody Name:
CACTIN Antibody (PACO07291)
Antibody SKU:
PACO07291
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:10000, WB:1:500-1:10000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide from human protein at AA range: 141-190
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method:
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of hepg2 cells using Antibody diluted at 1000. Secondary antibody was diluted at 1:20000.
Synonyms:
CACTIN C19orf29
UniProt Protein Function:
CACTIN: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing. Belongs to the CACTIN family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Spliceosome; RNA splicingChromosomal Location of Human Ortholog: 19p13.3Cellular Component: nucleoplasm; cytoplasm; nucleusMolecular Function: protein bindingBiological Process: nuclear mRNA splicing, via spliceosome; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of protein amino acid phosphorylation; inhibition of NF-kappaB transcription factor; multicellular organismal development; negative regulation of toll-like receptor signaling pathway; negative regulation of interleukin-8 production; innate immune response; negative regulation of tumor necrosis factor production; negative regulation of interferon-beta production
