The CACNG6 Polyclonal Antibody (PACO63915) is specifically designed for researchers studying the CACNG6 protein, a critical component in neuronal calcium channels. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the CACNG6 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential tool for research in neuroscience and neurology.CACNG6, also known as neuronal voltage-gated calcium channel gamma-6 subunit, plays a crucial role in regulating calcium influx in neurons, influencing neuronal excitability and synaptic transmission.
Understanding the functions of CACNG6 is vital for studying neuronal signaling pathways and synaptic plasticity, with implications for neurological disorders such as epilepsy and Alzheimer's disease. This antibody provides researchers with a valuable tool for investigating the role of CACNG6 in neuronal function and dysfunction, paving the way for potential therapeutic interventions in neurological conditions.
Antibody Name:
CACNG6 Antibody (PACO63915)
Antibody SKU:
PACO63915
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Peptide sequence from Human Voltage-dependent calcium channel gamma-6 subunit protein (22-39AA)
Immunofluorescence staining of A549 cells with PACO63915 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Thought to stabilize the calcium channel in an inactivated (closed) state.
CACNG6: Thought to stabilize the calcium channel in an inactivated (closed) state. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 19q13.4Cellular Component: plasma membrane
UniProt Protein Details:
NCBI Summary:
Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). Alternative splicing results in multiple transcript variants. Variants in this gene have been associated with aspirin-intolerant asthma. [provided by RefSeq, Dec 2010]
