The CACNG5 Polyclonal Antibody (PACO07025) is a valuable tool for researchers studying CACNG5, a protein involved in calcium channel regulation and neuronal function. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the CACNG5 protein, researchers can easily detect and analyze this important molecule in a variety of cell types.CACNG5 is known for its role in modulating calcium channel activity and synaptic transmission in the brain. It is also implicated in neurological disorders such as epilepsy and autism spectrum disorders.
With its involvement in these critical processes, studying CACNG5 with the PACO07025 antibody can provide valuable insights into neurobiology and potential therapeutic targets for neurological conditions.Overall, the CACNG5 Polyclonal Antibody (PACO07025) is an essential tool for researchers investigating the function of CACNG5 and its impact on neurological health. Its high reactivity and specificity make it a reliable choice for studies in neuroscience and pharmacology.
Antibody Name:
CACNG5 Antibody (PACO07025)
Antibody SKU:
PACO07025
Size:
50ug
Host Species:
Rabbit
Tested Applications:
WB, IHC
Recommended Dilutions:
WB:1:500-1:1000, IHC:1:100-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic Peptide
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method:
Affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of 1) Human Brain Tissue, 2) Mouse Brain Tissue, 3) Rat Brain Tissue using L-type Ca++ CP gamma 5 Polyclonal Antibody.
Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using L-type Ca++ CP gamma 5 Polyclonal Antibody.
Synonyms:
Voltage-dependent calcium channel γ-5 subunit
UniProt Protein Function:
CACNG5: Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 17q24Cellular Component: cell junction; plasma membrane; postsynaptic density; postsynaptic membraneMolecular Function: channel regulator activity; ion transmembrane transporter activity; voltage-gated calcium channel activityBiological Process: transmission of nerve impulse; transport
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010]
