The CACNG3 Polyclonal Antibody (PAC051374) is specifically designed for research involving CACNG3, a protein involved in calcium channel regulation and neuronal excitability. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot and immunohistochemistry applications. CACNG3, also known as the gamma-3 subunit of voltage-gated calcium channels, plays a crucial role in regulating calcium influx into cells, particularly in the nervous system. Dysregulation of CACNG3 has been implicated in various neurological disorders, including epilepsy and schizophrenia.
By targeting CACNG3 with this antibody, researchers can explore its role in neuronal signaling and potentially develop targeted therapies for these conditions.Overall, the CACNG3 Polyclonal Antibody (PAC051374) is a valuable tool for studying the function of CACNG3 in various cell types and tissues, making it an essential component for neuroscience and neurology research. Its high reactivity and specificity make it an ideal choice for researchers investigating the role of calcium channels in neurological disorders.
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).
Synonyms:
Voltage-dependent calcium channel gamma-3 subunit (Neuronal voltage-gated calcium channel gamma-3 subunit) (Transmembrane AMPAR regulatory protein gamma-3) (TARP gamma-3), CACNG3
UniProt Protein Function:
CACNG3: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Protein type: Membrane protein, multi-pass; Channel, calcium; Membrane protein, integralChromosomal Location of Human Ortholog: 16p12.1Cellular Component: plasma membraneMolecular Function: channel regulator activity; voltage-gated calcium channel activityBiological Process: transmission of nerve impulse
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy. [provided by RefSeq, Dec 2010]
