The CACNG3 Polyclonal Antibody (PACO08136) is a valuable tool for researchers studying the CACNG3 protein, which is involved in calcium channel regulation in cells. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the CACNG3 protein, this antibody allows for the detection and analysis of CACNG3 in a variety of cell types, making it an ideal choice for studies in neuroscience and cell biology.CACNG3 is a critical component of calcium channels and plays a key role in regulating calcium influx into cells, which is essential for various cellular processes including neurotransmission and muscle contraction.
Dysregulation of CACNG3 has been implicated in neurological disorders such as epilepsy and Alzheimer's disease, making it an important target for research in these areas. Understanding the function of CACNG3 can provide valuable insights into the mechanisms underlying these diseases and may lead to the development of novel therapeutic strategies.
CACNG3: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Protein type: Membrane protein, multi-pass; Channel, calcium; Membrane protein, integralChromosomal Location of Human Ortholog: 16p12.1Cellular Component: plasma membraneMolecular Function: channel regulator activity; voltage-gated calcium channel activityBiological Process: transmission of nerve impulse
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy. [provided by RefSeq, Dec 2010]
