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CACNG3 Antibody (PACO07022)

SKU:
PACO07022
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • CACNG3 Antibody PACO07022
  • CACNG3 Antibody PACO07022
€269

Description

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CACNG3 Antibody (PACO07022)

The CACNG3 Polyclonal Antibody (PACO07022) is a vital tool for researchers studying CACNG3, a protein involved in neuronal calcium channel regulation. This antibody, produced in rabbits, is specifically reactive with human samples and has been validated for use in Western blotting applications. It binds to the CACNG3 protein, allowing for precise detection and analysis in a variety of cell types, making it ideal for studies in neuroscience and neurology.CACNG3, also known as gamma-3 subunit of calcium channel, plays a crucial role in regulating calcium influx in neurons, impacting neuronal excitability and synaptic transmission.

Research on CACNG3 is important for understanding neurological disorders such as epilepsy, Alzheimer's disease, and Parkinson's disease, where abnormalities in calcium signaling pathways are implicated. By investigating the function of CACNG3, researchers can gain insights into potential therapeutic targets for these conditions, leading to the development of new treatments and interventions.

Antibody Name:CACNG3 Antibody (PACO07022)
Antibody SKU:PACO07022
Size:50ug
Host Species:Rabbit
Tested Applications:WB, IHC
Recommended Dilutions:WB:1:1000-1:2000, IHC:1:200-1:500
Species Reactivity:Human, Mouse, Rat
Immunogen:Synthetic Peptide
Form:Liquid
Storage Buffer:PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method:Affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of 1) Human Brain Tissue, 2) Mouse Brain Tissue, 3) Rat Brain Tissue using CACNG3 Polyclonal Antibody.
Product ImageImmunohistochemical analysis of paraffin-embedded Rat Brain Tissue using CACNG3 Polyclonal Antibody.
Synonyms:Voltage-dependent calcium channel γ-3 subunit
UniProt Protein Function:CACNG3: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Protein type: Membrane protein, multi-pass; Channel, calcium; Membrane protein, integralChromosomal Location of Human Ortholog: 16p12.1Cellular Component: plasma membraneMolecular Function: channel regulator activity; voltage-gated calcium channel activityBiological Process: transmission of nerve impulse
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy. [provided by RefSeq, Dec 2010]
UniProt Code:O60359
NCBI GenInfo Identifier:6685277
NCBI Gene ID:10368
NCBI Accession:O60359.1
UniProt Secondary Accession:O60359
UniProt Related Accession:O60359
Molecular Weight:35,549 Da
NCBI Full Name:Voltage-dependent calcium channel gamma-3 subunit
NCBI Synonym Full Names:calcium voltage-gated channel auxiliary subunit gamma 3
NCBI Official Symbol:CACNG3  
NCBI Official Synonym Symbols:
NCBI Protein Information:voltage-dependent calcium channel gamma-3 subunit
UniProt Protein Name:Voltage-dependent calcium channel gamma-3 subunit
UniProt Synonym Protein Names:Neuronal voltage-gated calcium channel gamma-3 subunit; Transmembrane AMPAR regulatory protein gamma-3; TARP gamma-3
Protein Family:Voltage-dependent calcium channel
UniProt Gene Name:CACNG3  
UniProt Entry Name:CCG3_HUMAN
Antibodies
CACNG3 Antibody (PACO08136)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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