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Anti-CACNB4 Antibody (CAB9304)

SKU:
CAB9304
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

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Anti-CACNB4 Antibody (CAB9304)

The CACNB4 Polyclonal Antibody (CAB9304) is a valuable tool for researchers studying the CACNB4 protein, which is involved in various cellular processes, particularly in the regulation of calcium channels. This antibody is raised in rabbits and has been validated for use in Western blot applications with high reactivity to human samples.CACNB4, also known as the calcium channel beta-4 subunit, plays a crucial role in regulating calcium influx into cells, which is essential for signal transduction and cellular functions. Dysregulation of CACNB4 has been linked to various diseases, including cardiac arrhythmias, epilepsy, and neurological disorders.

By targeting CACNB4 using this antibody, researchers can study its expression and function in different cell types and gain insight into its role in health and disease.By understanding the mechanisms by which CACNB4 functions, researchers may uncover new therapeutic targets for treating conditions associated with calcium channel dysfunction. The CACNB4 Polyclonal Antibody is a valuable tool for advancing research in the fields of neuroscience, cardiology, and molecular biology.

Antibody Name:Anti-CACNB4 Antibody
Antibody SKU:CAB9304
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 401-520 of human CACNB4 (NP_000717.2).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 401-520 of human CACNB4 (NP_000717.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ATHT TSST PMTP LLGR NLGS TALS PYPT AISG LQSQ RMRH SNHS TENS PIER RSLM TSDE NYHN ERAR KSRN RLSS SSQH SRDH YPLV EEDY PDSY QDTY KPHR NRGS PGGY SHDS RHRL
Gene ID:785
Uniprot:O00305
Cellular Location:
Calculated MW:51kDa/54kDa/56kDa/58kDa
Observed MW:58kDa
Synonyms:CACNB4, CAB4, CACNLB4, EA5, EIG9, EJM, EJM4, EJM6
Background:This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Summary:This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE), juvenile myoclonic epilepsy (JME), and episodic ataxia, type 5. [provided by RefSeq, Aug 2016]
UniProt Code:O00305
NCBI GenInfo Identifier:54607064
NCBI Gene ID:785
NCBI Accession:NP_000717
UniProt Related Accession:O00305
Molecular Weight:
NCBI Full Name:voltage-dependent L-type calcium channel subunit beta-4 isoform b
NCBI Synonym Full Names:calcium voltage-gated channel auxiliary subunit beta 4
NCBI Official Symbol:CACNB4  
NCBI Official Synonym Symbols:EA5; EJM; CAB4; EIG9; EJM4; EJM6; CACNLB4  
NCBI Protein Information:voltage-dependent L-type calcium channel subunit beta-4
UniProt Protein Name:Voltage-dependent L-type calcium channel subunit beta-4
UniProt Synonym Protein Names:Calcium channel voltage-dependent subunit beta 4
UniProt Gene Name:CACNB4  
UniProt Entry Name:CACB4_HUMAN
Anti-CACNB4 Polyclonal Antibody (CAB9304)Western blot analysis of extracts of various cell lines, using CACNB4 antibody (CAB9304) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.

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