Anti-CACNB3 Antibody (CAB14710)

Antibody Name:	Anti-CACNB3 Antibody
Antibody SKU:	CAB14710
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 355-484 of human CACNB3 (NP_000716.2).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Mouse, Rat
Positive Samples:	Mouse brain, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 355-484 of human CACNB3 (NP_000716.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	VYWR ATHH PAPG PGLL GPPS AIPG LQNQ QLLG ERGE EHSP LERD SLMP SDEA SESS RQAW TGSS QRSS RHLE EDYA DAYQ DLYQ PHRQ HTSG LPSA NGHD PQDR LLAQ DSEH NHSD RNWQ RNRP WPKD SY
Gene ID:	784
Uniprot:	P54284
Cellular Location:
Calculated MW:	50kDa/53kDa/54kDa
Observed MW:	58kDa

Synonyms:	CACNB3, CAB3, CACNLB3
Background:	This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport.

UniProt Protein Function:	CACNB3: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Belongs to the calcium channel beta subunit family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Channel, calcium Chromosomal Location of Human Ortholog: 12q13 Cellular Component: cytosol; membrane; plasma membrane; voltage-gated calcium channel complex Molecular Function:calcium channel activity; high voltage-gated calcium channel activity; voltage-gated calcium channel activity Biological Process: calcium ion transport; membrane depolarization; neuromuscular junction development; synaptic transmission; transport
NCBI Summary:	This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]
UniProt Code:	P54284
NCBI GenInfo Identifier:	1705683
NCBI Gene ID:	784
NCBI Accession:	P54284.1
UniProt Secondary Accession:	P54284,Q13913, A8K0Z4, B7Z4Q1, B7Z973, B7ZAK8, F5GZW7 F5H2P6, F8VSG3,
UniProt Related Accession:	P54284
Molecular Weight:	50,015 Da
NCBI Full Name:	Voltage-dependent L-type calcium channel subunit beta-3
NCBI Synonym Full Names:	calcium voltage-gated channel auxiliary subunit beta 3
NCBI Official Symbol:	CACNB3
NCBI Official Synonym Symbols:	CAB3; CACNLB3
NCBI Protein Information:	voltage-dependent L-type calcium channel subunit beta-3
UniProt Protein Name:	Voltage-dependent L-type calcium channel subunit beta-3
UniProt Synonym Protein Names:	Calcium channel voltage-dependent subunit beta 3
Protein Family:	Voltage-dependent L-type calcium channel
UniProt Gene Name:	CACNB3
UniProt Entry Name:	CACB3_HUMAN

	Western blot analysis of extracts of various cell lines, using CACNB3 antibody (CAB14710) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded rat ovary using CACNB3 antibody (CAB14710) at dilution of 1:150 (40x lens).

Antibodies

CACNB3 Antibody (PACO07020)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)