CACNA2D2 Rabbit Polyclonal Antibody (CAB10267)
- SKU:
- CAB10267
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | CACNA2D2 Rabbit Polyclonal Antibody |
SKU: | CAB10267 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human CACNA2D2 (NP_001167522.1). |
Sequence: | RPWP GCGP HPGP GTRR PTSG PPRP LWLL LPLL PLLA APGA SAYS FPQQ HTMQ HWAR RLEQ EVDG VMRI FGGV QQLR EIYK DNRN LFEV QENE PQKL VEKV AGDI ESLL DRKV QALK RLAD AAEN FQKA HRWQ DNIK EEDI VYYD AKAD AELD DPES EDVE RGSK ASTL RLDF IEDP NFKN K |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:200 - 1:2000 |
Synonyms: | CASVDD; CACNA2D; CACNA2D2 |
Positive Sample: | Mouse brain,Rat heart,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein. |
Calculated MW: | 130kDa |
Observed MW: | 140-160kDa |
Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 9254 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |