The CACNA2D2 Polyclonal Antibody (CAB10267) is specifically designed for research involving CACNA2D2, a protein involved in calcium channel regulation in cells. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the CACNA2D2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in neuroscience and cardiovascular research.CACNA2D2 plays a crucial role in regulating calcium entry into cells, which is essential for neurotransmitter release and muscle contraction. Dysregulation of CACNA2D2 has been linked to neurological disorders like epilepsy and cardiovascular diseases like arrhythmias.
Understanding the function of CACNA2D2 is vital for advancing research and developing therapies for these conditions.By using the CACNA2D2 Polyclonal Antibody (CAB10267), researchers can gain insights into the role of CACNA2D2 in cellular processes and potentially identify novel targets for therapeutic intervention. Its versatility in detecting CACNA2D2 in various cell types makes it a valuable tool for scientists studying calcium channel signaling pathways and their implications in human health and disease.
Product Name:
CACNA2D2 Rabbit Polyclonal Antibody
SKU:
CAB10267
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human CACNA2D2 (NP_001167522.1).
Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
9254
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CACNA2D2 Rabbit pAb (CAB10267) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 1s.
