The CACNA2D1 Polyclonal Antibody (CAB15260) is a powerful tool for researchers studying the CACNA2D1 protein, which is involved in calcium channel regulation and has been implicated in various diseases, including neurological disorders and cancer. This antibody is produced in rabbits and has been extensively validated for use in Western blot applications, where it specifically binds to the CACNA2D1 protein.The CACNA2D1 protein is a subunit of voltage-dependent calcium channels, which play a crucial role in neurotransmission, muscle contraction, and other cellular processes. Dysregulation of CACNA2D1 has been linked to conditions such as epilepsy and Parkinson's disease, making it a promising target for therapeutic development.
By using the CACNA2D1 Polyclonal Antibody, researchers can accurately detect and analyze the protein in various cell types, facilitating further investigations into its functions and potential roles in disease pathology.Overall, the CACNA2D1 Polyclonal Antibody is an essential tool for scientists interested in unraveling the molecular mechanisms of calcium channel regulation and its implications in health and disease. Its high reactivity and specificity make it a valuable asset for studies in neuroscience, pharmacology, and cancer research.
Product Name:
CACNA2D1 Rabbit Polyclonal Antibody
SKU:
CAB15260
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 550-800 of human CACNA2D1 (NP_000713.2).
The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion.
Purification Method:
Affinity purification
Gene ID:
781
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CACNA2D1 Rabbit pAb (CAB15260) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5S.
