The CACNA1I Polyclonal Antibody (PACO07169) is a powerful tool for researchers studying the CACNA1I protein, a key player in calcium channel regulation. This antibody, developed in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.The CACNA1I protein is involved in the regulation of calcium influx in cells, making it essential for processes such as neurotransmitter release and muscle contraction. Dysregulation of calcium channels, including CACNA1I, has been linked to various diseases, including neurological disorders and cardiac arrhythmias.
By using the CACNA1I Polyclonal Antibody, researchers can effectively detect and analyze CACNA1I protein levels in different cell types, contributing valuable insights to studies in neuroscience, cardiology, and pharmacology. Understanding the role of CACNA1I in calcium channel function is crucial for developing targeted therapies for conditions associated with calcium channel dysfunction.
Antibody Name:
CACNA1I Antibody (PACO07169)
Antibody SKU:
PACO07169
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC-p:1:100-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic Peptide
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemical analysis of paraffin-embedded Mouse Brain Tissue using Cav3.3Rabbit pAb diluted at 1:200.
Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using Cav3.3Rabbit pAb diluted at 1:200.
UniProt Protein Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H ().
UniProt Protein Details:
NCBI Summary:
This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
