The CACNA1E Polyclonal Antibody (CAB10203) is a powerful tool for researchers studying the CACNA1E protein, a crucial component of calcium channels in the nervous system. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.CACNA1E is a voltage-gated calcium channel involved in neurotransmitter release, neuronal excitability, and synaptic plasticity. Dysregulation of CACNA1E has been linked to neurological disorders such as epilepsy, ataxia, and developmental delay.
By targeting the CACNA1E protein, researchers can gain insights into the underlying mechanisms of these conditions and potential therapeutic strategies.With its specificity and reliability, the CACNA1E Polyclonal Antibody is an essential tool for investigations in neuroscience, neurology, and pharmacology. Its ability to detect and analyze CACNA1E in various cell types makes it a valuable asset for advancing our understanding of calcium channel function and its implications in neurological health and disease.
Product Name:
CACNA1E Rabbit Polyclonal Antibody
SKU:
CAB10203
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2014-2313 of human CACNA1E (NP_001192222.1).
Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
777
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CACNA1E antibody (CAB10203) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
