The CABP1 Polyclonal Antibody (CAB18406) is a valuable tool for researchers studying the CABP1 protein, which is involved in calcium signaling pathways and is crucial for neuronal function. This rabbit polyclonal antibody is highly specific to human samples and has been validated for use in Western blot and immunofluorescence applications.CABP1, also known as calcium-binding protein 1, is essential for the regulation of intracellular calcium levels and synaptic transmission in neurons. Dysregulation of CABP1 has been linked to neurological disorders such as epilepsy and Alzheimer's disease, making it an important target for research in neuroscience and neurodegenerative diseases.
By using the CABP1 Polyclonal Antibody, researchers can accurately detect and analyze the expression of CABP1 in various cell types, providing valuable insights into its function and potential therapeutic implications. This antibody is a valuable tool for investigating the role of CABP1 in neuronal signaling and neurodegenerative conditions, ultimately advancing our understanding of these complex diseases.
Product Name:
CABP1 Rabbit Polyclonal Antibody
SKU:
CAB18406
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CABP1 (NP_001028849.1).
cell cortex, cytoplasm, cytoskeleton, extracellular space, perinuclear region of cytoplasm, plasma membrane, postsynaptic density
Calculated MW:
40kDa
Observed MW:
25kDa
Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms.
Purification Method:
Affinity purification
Gene ID:
9478
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CABP1 Rabbit pAb (CAB18406) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
