The Cables2 Monoclonal Antibody (PAC019370) is a specific and high-quality antibody designed for research involving Cables2, a protein implicated in various cellular processes such as cell cycle regulation and cell proliferation. This antibody, produced in mice, is highly reactive with human samples and is validated for use in Western blot and immunofluorescence applications. It binds specifically to the Cables2 protein, enabling accurate detection and analysis in various cell types, making it an ideal tool for studies in cell biology, cancer research, and developmental biology.Cables2, also known as CDK5 and Abl enzyme substrate 2, plays a crucial role in cell cycle progression and is involved in mediating the DNA damage response.
Its significance in regulating cell division makes it a valuable target for research into diseases like cancer, where uncontrolled cell proliferation is a hallmark. Studying the function of Cables2 can provide insights into potential therapeutic strategies for cancer treatment and other proliferative disorders. This PAC019370 antibody provides researchers with a reliable tool to investigate the role of Cables2 in various cellular processes, enabling a better understanding of its function and potential implications for disease pathology.
Antibody Name:
CABLES2 Antibody (PACO19370)
Antibody SKU:
PACO19370
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human CABLES2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19370(CABLES2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19370(CABLES2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Cables2 (Cdk5 and ABL1 enzyme substrate 2), also known as Ik3-2, is a 478 amino acid, ubiquitously expressed protein that has a C-terminal cyclin box-containing domain, making it a member of the cyclin protein superfamily. A related protein, Cables, forms a trimolecular complex with Cdk5 and c-Abl in vivo, enhances apoptosis induced by overexpression of p53 and may be a tumor suppressor, due to its chromosomal loss of heterozygosity that is found in certain cancers. Cables2 shares 78% sequence similarity with Cables in the region of the cyclin box-containing domain and, in similar functionality, associates with Cdk3, Cdk5 and c-Abl. However, unlike its close relative, Cables2 also contains an N-terminal region that enhances not only p53-mediated cell death, but also p53-independent cell death. This characteristic suggests that the gene encoding Cables2 may also function as a tumor suppressor gene.
Synonyms:
Cdk5 and Abl enzyme substrate 2
UniProt Protein Function:
CABLES2: Unknown. Probably involved in G1-S cell cycle transition. Belongs to the cyclin family.