The Cables1 Polyclonal Antibody (CAB10335) is a valuable tool for researchers studying Cables1, a protein involved in cell cycle regulation and tumor suppression. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically binds to the Cables1 protein, allowing for accurate detection and analysis in various cell types.Cables1 is known to interact with cyclin-dependent kinase 2 (CDK2) and cyclin A, controlling cell cycle progression and inhibiting cell proliferation.
Its role as a tumor suppressor gene makes it a promising target for cancer research, as dysregulation of Cables1 has been implicated in various types of cancer. By studying the function of Cables1, researchers can gain insights into mechanisms of tumorigenesis and potentially identify novel therapeutic strategies for cancer treatment.
Product Name:
CABLES1 Rabbit Polyclonal Antibody
SKU:
CAB10335
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-368 of human CABLES1 (NP_612384.1).
This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
91768
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CABLES1 antibody (CAB10335) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
