The CA8 Polyclonal Antibody (CAB7544) is a high-quality research tool designed for the investigation of CA8, a critical protein involved in various cellular processes. This antibody, produced in rabbits, exhibits strong reactivity towards human samples and has been validated for use in Western blot applications. By specifically binding to the CA8 protein, researchers can accurately detect and analyze CA8 expression in a variety of cell types, making it an excellent choice for studies in biochemistry and cell biology.CA8, also known as carbonic anhydrase VIII, is essential for the regulation of pH balance and carbon dioxide transportation in cells.
Dysregulation of CA8 has been linked to various diseases, including cancer, neurological disorders, and metabolic conditions. By investigating the function of CA8, researchers can gain valuable insights into the underlying mechanisms of these pathologies and potentially develop new therapeutic strategies targeting this protein.Overall, the CA8 Polyclonal Antibody (CAB7544) is a valuable tool for researchers interested in exploring the role of CA8 in health and disease. Its high specificity and sensitivity make it ideal for a wide range of experimental applications, furthering our understanding of the crucial functions of this important protein.
Product Name:
CA8 Rabbit Polyclonal Antibody
SKU:
CAB7544
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human CA8 (NP_004047.3).
The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
767
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CA8 Rabbit pAb (CAB7544) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
