The CA5A Polyclonal Antibody (CAB14709) is a valuable tool for researchers studying CA5A, a key enzyme involved in carbon dioxide hydration and bicarbonate transport in the body. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the CA5A protein, this antibody enables the detection and analysis of CA5A in various cell types, making it ideal for investigations in physiology and disease research.CA5A, also known as carbonic anhydrase VA, plays a crucial role in maintaining acid-base balance and pH regulation in tissues.
Dysregulation of CA5A has been linked to various disorders, including metabolic acidosis, kidney stones, and certain cancers. Understanding the function and expression of CA5A is essential for developing targeted therapies and diagnostic tools for these conditions.Overall, the CA5A Polyclonal Antibody is a reliable reagent for researchers aiming to explore the physiological and pathological roles of CA5A in health and disease. Its versatility and specificity make it a valuable asset in advancing our knowledge of carbonic anhydrase biology and its clinical implications.
Product Name:
CA5A Rabbit Polyclonal Antibody
SKU:
CAB14709
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 39-305 of human CA5A (NP_001730.1).
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis. CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2.
Purification Method:
Affinity purification
Gene ID:
763
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse liver using CA5A Rabbit pAb(CAB14709) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime:5s.
