The CA11 Polyclonal Antibody (PACO08121) is a valuable tool for researchers studying CA11, an important protein involved in various cellular processes. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the CA11 protein, this antibody allows for the detection and analysis of CA11 in different cell types, making it an ideal choice for studies in molecular biology and cell signaling.CA11, also known as carbonic anhydrase 11, plays a crucial role in maintaining pH balance in cells by catalyzing the reversible hydration of carbon dioxide.
It is involved in processes such as bone resorption, calcification, and renal acidification, making it a promising target for research in fields like metabolism, bone health, and kidney function. Understanding the function and regulation of CA11 is essential for advancing our knowledge of these physiological processes and potentially developing new therapies for related disorders.
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]
