The CA1 Polyclonal Antibody (CAB1031) is a valuable tool for research involving CA1, a key protein involved in cellular functions such as calcium signaling and neuronal communication. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in applications such as Western blotting. By binding to CA1, researchers can detect and analyze its expression in a variety of cell types, making it an ideal choice for studies in neuroscience and neurodegenerative diseases.
CA1, a member of the carbonic anhydrase family, plays a crucial role in maintaining pH balance and ion transport in cells. Dysregulation of CA1 has been linked to various neurological disorders, making it a potential target for drug development and therapeutic interventions. By studying the function and activity of CA1, researchers can gain insights into mechanisms underlying conditions such as Alzheimer's disease, epilepsy, and stroke, paving the way for novel treatment strategies.
Recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human Carbonic Anhydrase 1 (Carbonic Anhydrase 1 (CA1)) (NP_001122303.1).
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
759
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Carbonic Anhydrase 1 (Carbonic Anhydrase 1 (CA1)) antibody (CAB1031) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
