C9orf72 Rabbit Polyclonal Antibody (CAB15970)
- SKU:
- CAB15970
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Autophagy
Description
Product Name: | C9orf72 Rabbit Polyclonal Antibody |
SKU: | CAB15970 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 9-200 of human C9orf72 (NP_001242983.1). |
Sequence: | SPAV AKTE IALS GKSP LLAA TFAY WDNI LGPR VRHI WAPK TEQV LLSD GEIT FLAN HTLN GEIL RNAE SGAI DVKF FVLS EKGV IIVS LIFD GNWN GDRS TYGL SIIL PQTE LSFY LPLH RVCV DRLT HIIR KGRI WMHK ERQE NVQK IILE GTER MEDQ GQSI IPML TGEV IPVM ELLS SMKS HSVP EEID |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | ALSFTD; DENND9; FTDALS; DENNL72; FTDALS1; C9orf72 |
Positive Sample: | SH-SY5Y,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytoplasmic vesicle, Endosome, Lysosome, Nucleus, Secreted, autophagosome. |
Calculated MW: | 54kDa |
Observed MW: | 50kDa |
The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 203228 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |