The C8B Polyclonal Antibody (CAB8324) is a valuable tool for researchers studying C8B, a component of the complement system involved in immune response and inflammation. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in various applications, including Western blotting. By targeting the C8B protein, this antibody allows for the detection and analysis of C8B in different cell types, making it an essential reagent for studies in immunology and inflammatory conditions.
C8B is part of the complement system, a crucial component of the innate immune response that enhances the body's ability to fight infections and clear damaged cells. Dysregulation of the complement system, including C8B, has been linked to various diseases such as autoimmune disorders, inflammatory conditions, and infectious diseases. By understanding the role of C8B in these pathological processes, researchers can develop targeted therapies to manipulate the immune response effectively.
Product Name:
C8B Rabbit Polyclonal Antibody
SKU:
CAB8324
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 55-350 of human C8B (NP_000057.2).
This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
732
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using C8B antibody (CAB8324) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
