C7 Rabbit Polyclonal Antibody (CAB5394)
- SKU:
- CAB5394
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | C7 Rabbit Polyclonal Antibody |
SKU: | CAB5394 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 22-270 of human C7 (NP_000578.2). |
Sequence: | ASSP VNCQ WDFY APWS ECNG CTKT QTRR RSVA VYGQ YGGQ PCVG NAFE TQSC EPTR GCPT EEGC GERF RCFS GQCI SKSL VCNG DSDC DEDS ADED RCED SERR PSCD IDKP PPNI ELTG NGYN ELTG QFRN RVIN TKSF GGQC RKVF SGDG KDFY RLSG NVLS YTFQ VKIN NDFN YEFY NSTW SYVK HTST EHTS SSRK RSFF RSSS SSSR SYTS HTNE IHKG KSYQ LLVV ENTV EVAQ FINN NPEF L |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | C7 |
Positive Sample: | Mouse plasma,Rat plasma |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 94kDa |
Observed MW: | 100-105kDa |
This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency.
Purification Method: | Affinity purification |
Gene ID: | 730 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |