C4BPB Rabbit Polyclonal Antibody (CAB6362)
- SKU:
- CAB6362
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | C4BPB Rabbit Polyclonal Antibody |
SKU: | CAB6362 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-251 of human C4BPB (NP_001017364.1). |
Sequence: | ASDE HCPE LPPV DNSI FVAK EVEG QILG TYVC IKGY HLVG KKTL FCNA SKEW DNTT TECR LGHC PDPV LVNG EFSS SGPV NVSD KITF MCND HYIL KGSN RSQC LEDH TWAP PFPI CKSR DCDP PGNP VHGY FEGN NFTL GSTI SYYC EDRY YLVG VQEQ QCVD GEWS SALP VCKL IQEA PKPE CEKA LLAF QESK NLCE AMEN FMQQ LKES GMTM EELK YSLE LKKA ELKA KLL |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | C4BP; C4BPB |
Positive Sample: | Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 28kDa |
Observed MW: | 28kDa |
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 725 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |