The C4BPA Polyclonal Antibody (CAB7648) is a valuable tool for researchers studying the C4b-binding protein alpha chain (C4BPA) protein. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the C4BPA protein, this antibody allows for the detection and analysis of C4BPA in various cell types, making it an ideal choice for studies in immunology and infectious disease research.C4BPA is a key component of the innate immune system, playing a crucial role in the regulation of the complement system.
Dysregulation of C4BPA has been implicated in various inflammatory diseases, making it an important target for research into conditions such as sepsis, autoimmune disorders, and infectious diseases. By understanding the function and activity of C4BPA, researchers can gain insights into the mechanisms underlying these diseases and potentially develop new therapeutic strategies.
Product Name:
C4BPA Rabbit Polyclonal Antibody
SKU:
CAB7648
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human C4BPA (NP_000706.1).
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster.
Purification Method:
Affinity purification
Gene ID:
722
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Human plasma, using C4BPA antibody (CAB7648) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
