C4D Rabbit Monoclonal Antibody (CAB3545)
- SKU:
- CAB3545
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- C4
- C4A2
- C4A3
- C4A4
- C4A6
- C4AD
- C4S
- CO4
- CPAMD2
- RG
- Research Area:
- Immunology
Description
Product Name: | C4D Rabbit Monoclonal Antibody |
SKU: | CAB3545 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 940-1237 of human Complement C4A (P0C0L4). |
Sequence: | HREE LVYE LNPL DHRG RTLE IPGN SDPN MIPD GDFN SYVR VTAS DPLD TLGS EGAL SPGG VASL LRLP RGCG EQTM IYLA PTLA ASRY LDKT EQWS TLPP ETKD HAVD LIQK GYMR IQQF RKAD GSYA AWLS RDSS TWLT AFVL KVLS LAQE QVGG SPEK LQET SNWL LSQQ QADG SFQD PCPV LDRS MQGG LVGN DETV ALTA FVTI ALHH GLAV FQDE GAEP LKQR VEAS ISKA NSFL GEKA SAGL LGAH AAAI TAYA LTLT KAPV DLLG VAHN NLMA MAQE TGDN LYWG SVTG SQ |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | C4; RG; C4S; CO4; C4A2; C4A3; C4A4; C4A6; C4AD; CPAMD2; Complement C4A |
Positive Sample: | Hep G2 |
Conjugate: | Unconjugated |
Cellular Localization: | Axon, Blood microparticle, Classical-complement-pathway C3/C5 convertase complex, Dendrite, Endoplasmic reticulum lumen, Extracellular exosome, Extracellular region, Extracellular space, Plasma membrane, Synapse |
Calculated MW: | 193kDa |
Observed MW: | 200kDa |
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 720 |
Clone Number: | ARC2037 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |