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C3c Polyclonal Antibody

SKU:
CAB23938
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IF
$155 - $431
Frequently bought together:

Description

C3c Polyclonal Antibody (CAB23938)

The C3c Polyclonal Antibody is a critical tool for researchers studying the C3c protein, an essential component of the complement system involved in immune response regulation. This antibody, produced using rabbit immunization, exhibits high reactivity towards human samples and is validated for use in Western blotting applications. By specifically binding to the C3c protein, researchers can accurately detect and analyze its expression in various cell types, making it an invaluable tool for studies in immunology and inflammatory diseases.C3c, a key player in the complement system, plays a vital role in mediating immune responses by promoting inflammation and opsonization.

Dysregulation of C3c is associated with various diseases, including autoimmune disorders, infections, and inflammatory conditions. Understanding the functions of C3c is crucial for developing targeted therapies that modulate immune responses and combat disease progression.By utilizing the C3c Polyclonal Antibody, researchers can gain valuable insights into the role of C3c in immune regulation and disease pathogenesis. With its high specificity and sensitivity, this antibody is a valuable resource for investigators looking to uncover the mechanisms underlying immune dysregulation and develop novel therapeutic strategies.

Product Name:C3c Polyclonal Antibody
Product Code:CAB23938
Reactivity:Human
Applications:Western blotting, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human
Tested Applications:WB, IF/ICC, ELISA
Key Applications:Western blotting, Immunofluorescence
Recommended Dilution:WB 1:500-1:1000, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Positive Samples:Hep G2
Cellular Location:Secreted

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients.

Immunogen:Recombinant protein of human C3c.
Sequence:GRLKG PLLNK FLTTA KDKNR WEDPG KQLYN VEATS YALLA LLQLK DFDFV PPVVR WLNEQ RYYGG GYGST QATFM VFQAL AQYQK DAPDH QELNL DVSLQ L
Synonyms:ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p
Calculated MW:187kDa
Observed MW:187kDa

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