The C3 Polyclonal Antibody (CAB16781) is a vital tool for researchers studying the C3 protein, a key component of the complement system involved in immune response and inflammation. This rabbit-derived antibody is highly specific for human samples and is optimized for use in Western blotting applications. By binding to the C3 protein, this antibody allows for the detection and analysis of C3 levels in various cell types, making it an essential reagent for studies in immunology and inflammatory diseases.C3 is a central player in the complement system, an important part of the innate immune response responsible for recognizing and clearing pathogens, as well as promoting inflammation.
Dysregulation of the complement system, including C3, has been implicated in various diseases such as autoimmune disorders, inflammatory conditions, and infectious diseases. Therefore, investigating the role of C3 with the help of this antibody is crucial for understanding disease mechanisms and developing targeted therapies for related conditions.
Product Name:
C3 Rabbit Polyclonal Antibody
SKU:
CAB16781
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1159-1286 of mouse C3 (NP_033908.2).
This gene encodes complement protein C3 which plays a central role in the classical, alternative and lectin activation pathways of the complement system. The encoded preproprotein undergoes a multi-step processing to generate various functional peptides. Mice deficient in the encoded protein fail to clear bacteria from the blood stream upon infection, display diminished airway hyperresponsiveness and lung eosinophilia upon allergen-induced pulmonary allergy, and develop severe lung injury after deposition of IgG immune complexes. Deficiency of the homolog of the encoded protein in humans was found to be associated with increased susceptibility to infections, age-related macular degeneration, and atypical hemolytic uremic syndrome.
Purification Method:
Affinity purification
Gene ID:
12266
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of Rat lung, using C3 Rabbit pAb (CAB16781) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
