C3 Rabbit Polyclonal Antibody (CAB16781)
- SKU:
- CAB16781
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | C3 Rabbit Polyclonal Antibody |
SKU: | CAB16781 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1159-1286 of mouse C3 (NP_033908.2). |
Sequence: | EGQV NSLP GSIN KAGE YIEA SYMN LQRP YTVA IAGY ALAL MNKL EEPY LGKF LNTA KDRN RWEE PDQQ LYNV EATS YALL ALLL LKDF DSVP PVVR WLNE QRYY GGGY GSTQ ATFM VFQA LAQY QTDV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ASP; Plp; HSE-MSF; C3 |
Positive Sample: | Rat lung |
Cellular Localization: | cell surface, extracellular region, extracellular space, plasma membrane |
Calculated MW: | 186kDa |
Observed MW: | 115kDa |
This gene encodes complement protein C3 which plays a central role in the classical, alternative and lectin activation pathways of the complement system. The encoded preproprotein undergoes a multi-step processing to generate various functional peptides. Mice deficient in the encoded protein fail to clear bacteria from the blood stream upon infection, display diminished airway hyperresponsiveness and lung eosinophilia upon allergen-induced pulmonary allergy, and develop severe lung injury after deposition of IgG immune complexes. Deficiency of the homolog of the encoded protein in humans was found to be associated with increased susceptibility to infections, age-related macular degeneration, and atypical hemolytic uremic syndrome.
Purification Method: | Affinity purification |
Gene ID: | 12266 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |