The C2orf40 Antibody (PAC017812) is a high-quality polyclonal antibody specifically designed for research involving C2orf40, a protein with potential implications in various cellular processes. This antibody, generated in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. It binds to the C2orf40 protein, allowing for its detection and analysis in a wide range of cell types.C2orf40, also known as a potential cancer-related protein, is involved in cell growth, differentiation, and potentially tumorigenesis. Its role in cellular processes makes it a promising target for research in cancer biology and other related fields.
Understanding the function of C2orf40 could provide valuable insights into disease mechanisms and potential therapeutic strategies.Overall, the C2orf40 Antibody (PAC017812) is a valuable tool for researchers studying the function and role of C2orf40 in various cellular processes, particularly in the context of cancer research. Its high reactivity and validation for Western blot applications make it a reliable choice for immunology and cancer-related studies.
Antibody Name:
C2orf40 Antibody (PACO17812)
Antibody SKU:
PACO17812
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human C2orf40
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO17812(C2orf40 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17812(C2orf40 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
ECRG4 (esophageal cancer-related gene 4 protein), also known as augurin or C2orf40, is a 148 amino acid, secreted protein. Belonging to the augurin family, ECRG4 is thought to be a hormone. It has also been suggested that ECRG4 may act as a tumor suppressor. The gene that encodes ECRG4 maps to human chromosome 2, which consists of 237 million bases encoding over 1,400 genes, making up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr m syndrome is due to mutations in the ALMS1 gene. Interestingly, chromosome 2 contains what appears to be a vestigial second centromere and vestigial telomeres which gives credence to the hypothesis that human chromosome 2 is the result of an ancient fusion of two ancestral chromosomes.
Synonyms:
chromosome 2 open reading frame 40
UniProt Protein Function:
C2orf40: Probable hormone that may induce senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation. Belongs to the augurin family.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 2q12.2Cellular Component: extracellular space; transport vesicleBiological Process: cyclin catabolic process
