The C1S Polyclonal Antibody (CAB6878) is a high-quality research tool specifically designed for the study of C1S, a key component of the classical complement pathway involved in immune response regulation. Raised in rabbits, this antibody demonstrates high reactivity with human samples and is validated for use in Western blot applications. By targeting the C1S protein, researchers can effectively detect and analyze its expression in various cell types, making it an invaluable tool for investigations in immunology and inflammatory disease research.C1S, a serine protease, plays a crucial role in the activation of the complement cascade, a fundamental component of the immune system responsible for identifying and eliminating pathogens.
Dysregulation of the complement system, including abnormal C1S activity, has been linked to various diseases, such as autoimmune disorders, infections, and inflammatory conditions. By studying C1S expression and function, researchers can gain insight into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.Overall, the C1S Polyclonal Antibody (CAB6878) offers researchers a reliable tool for investigating the role of C1S in immune response modulation and disease pathogenesis. Its specificity and sensitivity make it an excellent choice for studies aimed at understanding the complex interplay between the complement system and immune regulation.
Product Name:
C1S Rabbit Polyclonal Antibody
SKU:
CAB6878
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 479-688 of human C1S (NP_958850.1).
blood microparticle, complement component C1 complex, extracellular region, extracellular space
Calculated MW:
77kDa
Observed MW:
77kDa
This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency.
Purification Method:
Affinity purification
Gene ID:
716
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using C1S Rabbit pAb (CAB6878) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
