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Anti-C1S Antibody (CAB13675)

SKU:
CAB13675
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • Immunology Antibodies 1 Anti-C1S Antibody CAB13675
  • Immunology Antibodies 1 Anti-C1S Antibody CAB13675
€139 - €419
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Description

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Antibody Name:Anti-C1S Antibody
Antibody SKU:CAB13675
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 479-688 of human C1S (NP_958850.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HepG2, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 479-688 of human C1S (NP_958850.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GNRE PTMY VGST SVQT SRLA KSKM LTPE HVFI HPGW KLLE VPEG RTNF DNDI ALVR LKDP VKMG PTVS PICL PGTS SDYN LMDG DLGL ISGW GRTE KRDR AVRL KAAR LPVA PLRK CKEV KVEK PTAD AEAY VFTP NMIC AGGE KGMD SCKG DSGG AFAV QDPN DKTK FYAA GLVS WGPQ CGTY GLYT RVKN YVDW IMKT MQEN STPR ED
Gene ID:716
Uniprot:P09871
Cellular Location:
Calculated MW:76kDa
Observed MW:100kDa
Synonyms:C1S, EDSPD2
Background:This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency.
UniProt Protein Function:C1S: C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. Defects in C1S are the cause of complement component C1s deficiency (C1SD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. Belongs to the peptidase S1 family.
UniProt Protein Details:

Protein type:EC 3.4.21.42; Protease

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: extracellular region

Molecular Function:identical protein binding; protein binding; serine-type endopeptidase activity; calcium ion binding

Biological Process: innate immune response; proteolysis; complement activation, classical pathway; complement activation

Disease: Complement Component C1s Deficiency

NCBI Summary:This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009]
UniProt Code:P09871
NCBI GenInfo Identifier:115205
NCBI Gene ID:716
NCBI Accession:P09871.1
UniProt Secondary Accession:P09871,Q9UCU7, Q9UCU8, Q9UCU9, Q9UCV0, Q9UCV1, Q9UCV2 Q9UCV3, Q9UCV4, Q9UCV5, Q9UM14, D3DUT4,
UniProt Related Accession:P09871
Molecular Weight:76,684 Da
NCBI Full Name:Complement C1s subcomponent
NCBI Synonym Full Names:complement component 1, s subcomponent
NCBI Official Symbol:C1S  
NCBI Protein Information:complement C1s subcomponent; C1 esterase; basic proline-rich peptide IB-1; complement component 1 subcomponent s
UniProt Protein Name:Complement C1s subcomponent
UniProt Synonym Protein Names:C1 esterase; Complement component 1 subcomponent sCleaved into the following 2 chains:Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain
UniProt Gene Name:C1S  
UniProt Entry Name:C1S_HUMAN
Anti-C1S Antibody (CAB13675)Western blot analysis of extracts of various cell lines, using C1S antibody (CAB13675) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-C1S Antibody (CAB13675)Immunofluorescence analysis of HeLa cells using C1S antibody (CAB13675).

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