The C1s Polyclonal Antibody (CAB13282) is a vital tool for research involving the C1s protein, a key component of the classical complement pathway. This antibody, produced using rabbits as the host, demonstrates high reactivity with human samples and has been validated for use in a variety of applications, including Western blotting.C1s is an essential serine protease involved in the activation of the complement system, a crucial part of the immune response that helps identify and eliminate pathogens. Dysregulation of the complement pathway, including abnormalities in C1s function, has been linked to various autoimmune disorders and inflammatory conditions.
By targeting the C1s protein, researchers can study its role in complement activation and its implications for inflammatory diseases. This antibody enables the detection and analysis of C1s in different cell types, making it valuable for studies in immunology, inflammation, and autoimmune research. Understanding the function of C1s is essential for developing targeted therapies that modulate the complement system and its involvement in various disease processes.
Product Name:
C1S Rabbit Polyclonal Antibody
SKU:
CAB13282
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human C1S (NP_001725.1).
blood microparticle, complement component C1 complex, extracellular region, extracellular space
Calculated MW:
77kDa
Observed MW:
88kDa
This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency.
Purification Method:
Affinity purification
Gene ID:
716
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse heart, using C1S Rabbit pAb (CAB13282) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
