The C1RL Antibody (PAC07453) is a polyclonal antibody designed for research involving the C1RL protein, a key component in the complement system. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blot and immunohistochemistry. By binding to the C1RL protein, this antibody allows for the detection and analysis of C1RL in different cell types, making it a valuable tool for studies in immunology and inflammatory diseases.The C1RL protein is known for its role in the activation of the complement system, a crucial part of the immune response that helps to eliminate pathogens and damaged cells.
Dysregulation of the complement system, including abnormal C1RL activity, has been implicated in various diseases, such as autoimmune disorders, neurodegenerative conditions, and inflammatory disorders. Research into the function and regulation of C1RL is essential for understanding these disease processes and developing targeted therapies to modulate the complement system effectively.
Antibody Name:
C1RL Antibody (PACO07453)
Antibody SKU:
PACO07453
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:10000-1:20000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from human C1RL. at AA range: 371-420
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of hela cells using primary antibody diluted at 1:500(4°C overnight). Secondary antibody:Goat Anti-rabbit IgG IRDye 800( diluted at 1:5000, 25°C, 1 hour).
Synonyms:
Complement C1r subcomponent-like protein (C1r-LP) (C1r-like protein) (EC 3.4.21) (C1r-like serine protease analog protein) (CLSPa)
UniProt Protein Function:
C1RL: Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum. Belongs to the peptidase S1 family.Protein type: EC 3.4.21.-; Protease; Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 12p13.31Cellular Component: extracellular spaceMolecular Function: serine-type endopeptidase activityBiological Process: innate immune response; proteolysis; complement activation, classical pathway
