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C1QBP Monoclonal Antibody [PAT1G7AT] (CPAB0622)

SKU:
CPAB0622
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2b
Clone:
PAT1G7AT
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

C1QBP Monoclonal Antibody [PAT1G7AT] (CPAB0622)

The C1QBP Polyclonal Antibody (CPAB0622) is a valuable tool for researchers studying C1QBP, a multifunctional protein involved in immune regulation and mitochondrial function. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot and immunohistochemistry applications. By binding specifically to C1QBP, this antibody allows for the precise detection and analysis of this important protein in a variety of cell types.C1QBP, also known as gC1qR, is known to play a crucial role in various biological processes, including immune response modulation, mitochondrial protein import, and cell proliferation.

Its involvement in these pathways makes it a promising target for research in immunology, cancer biology, and mitochondrial dysfunction. Understanding the function and regulation of C1QBP can provide insights into disease mechanisms and potential therapeutic strategies for conditions such as cancer and mitochondrial disorders.Overall, the C1QBP Polyclonal Antibody (CPAB0622) is a valuable tool for researchers interested in studying the role of C1QBP in health and disease. Its high specificity and reactivity make it an ideal choice for experiments aimed at elucidating the molecular mechanisms underlying the functions of this important protein.

Product Name:C1QBP Antibody
Product Sku:CPAB0622
Size:5μg
Host Species:Mouse
Immunogen:Anti-human C1QBP mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human C1QBP protein 74-282 amino acids purified from Ecoli.
Clone:PAT1G7AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:C1QBP antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2b
Background:C1QBP binds to the globular "heads" of c1q thus inhibiting c1 activation. C1QBP interacts with a wide range of ligands and is implicated in cell signaling. C1QBP associates with C1r and C1s in order to yield the first component of the serum complement system. C1QBP protein has been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. C1QBP is a new marker of tumor cells and tumor-associated macrophages/myeloid cells in hypoxic/metabolically deprived areas of tumors. Mitochondrial C1QBP is a critical mediator of p14ARF-induced apoptosis. C1QBP functions as a chemotactic factor for immature dendritic cells, and migration is mediated through ligation of both C1QBP and cC1qR/CR. C1QBP overexpression successfully blocks mRNA accumulation from the adenovirus major late transcription unit (MLTU) and stimulates RNA polymerase II carboxy-terminal domain phosphorylation in virus-infected cells. C1QBP binds with Hepacivirus core protein on CD8+ and CD4+ positive t-cells and inactivates lck and akt.
Synonyms:p32, HABP1, gC1Qr, GC1QBP, SF2p32, gC1Q-R, Complement component 1 Q subcomponent-binding protein mitochondrial, Glycoprotein gC1qBP, C1qBP, GC1q-R protein, Hyaluronan-binding protein 1, Mitochondrial matrix protein p32, p33, C1QBP.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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