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Anti-C1QA Antibody (CAB1821)

SKU:
CAB1821
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology
€139 - €419
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Description

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Antibody Name:Anti-C1QA Antibody
Antibody SKU:CAB1821
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 23-245 of human C1QA (NP_057075.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse lung, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 23-245 of human C1QA (NP_057075.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EDLC RAPD GKKG EAGR PGRR GRPG LKGE QGEP GAPG IRTG IQGL KGDQ GEPG PSGN PGKV GYPG PSGP LGAR GIPG IKGT KGSP GNIK DQPR PAFS AIRR NPPM GGNV VIFD TVIT NQEE PYQN HSGR FVCT VPGY YYFT FQVL SQWE ICLS IVSS SRGQ VRRS LGFC DTTN KGLF QVVS GGMV LQLQ QGDQ VWVE KDPK KGHI YQGS EADS VFSG FLIF PSA
Gene ID:712
Uniprot:P02745
Cellular Location:Secreted
Calculated MW:26kDa
Observed MW:25kDa
Synonyms:C1QA
Background:This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q.
UniProt Protein Function:C1QA iso2: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2 )-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: complement component C1 complex; extracellular region

Molecular Function:protein binding; serine-type endopeptidase activity

Biological Process: cell-cell signaling; complement activation; complement activation, classical pathway

Disease: C1q Deficiency

NCBI Summary:This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008]
UniProt Code:P02745
NCBI GenInfo Identifier:399138
NCBI Gene ID:712
NCBI Accession:P02745.2
UniProt Secondary Accession:P02745,Q5T963, B2R4X2,
UniProt Related Accession:P02745
Molecular Weight:26,017 Da
NCBI Full Name:Complement C1q subcomponent subunit A
NCBI Synonym Full Names:complement C1q A chain
NCBI Official Symbol:C1QA  
NCBI Protein Information:complement C1q subcomponent subunit A
UniProt Protein Name:Complement C1q subcomponent subunit A
Protein Family:Complement C1q subcomponent
UniProt Gene Name:C1QA  
UniProt Entry Name:C1QA_HUMAN
Anti-C1QA Antibody (CAB1821)Western blot analysis of extracts of various cell lines, using C1QA Antibody (CAB1821) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020).

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