The C17orf47 Polyclonal Antibody (PACO39698) is a versatile tool for researchers studying the C17orf47 protein, a potential tumor suppressor involved in regulating cell growth and differentiation. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including immunofluorescence and flow cytometry.C17orf47, also known as DDX47, is a promising target for cancer research due to its role in cell proliferation and apoptosis. By binding to the C17orf47 protein, this antibody enables the specific detection and analysis of C17orf47 expression in different cell types, facilitating studies on the mechanisms underlying tumorigenesis and potential therapeutic interventions.
In-depth understanding of the functions and regulatory mechanisms of C17orf47 is essential for developing novel treatment strategies for cancer and other diseases associated with dysregulated cell growth. The C17orf47 Polyclonal Antibody is a valuable resource for scientists seeking to unravel the complexities of C17orf47 biology and its implications in human health.
Antibody Name:
C17orf47 Antibody (PACO39698)
Antibody SKU:
PACO39698
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Uncharacterized protein C17orf47 protein (1-300AA)
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO39698 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO39698 at dilution of 1:100.
Synonyms:
Uncharacterized protein C17orf47, C17orf47
UniProt Protein Function:
SEPT4: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli. Belongs to the septin family. 6 isoforms of the human protein are produced by alternative splicing.Protein type: Cytoskeletal; Hydrolase; Cell development/differentiation; ApoptosisChromosomal Location of Human Ortholog: 17q22Cellular Component: cytoskeleton; mitochondrion; nucleusMolecular Function: GTPase activity; protein binding; GTP binding; structural molecule activityBiological Process: regulation of apoptosis; sperm mitochondrion organization and biogenesis; positive regulation of protein ubiquitination; cell division; positive regulation of apoptosis; metabolic process; apoptosis; brain development; cell cycle; sperm capacitation
UniProt Protein Details:
NCBI Summary:
This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]
Apoptosis-related protein in the TGF-beta signaling pathway; ARTS; Bradeion beta; Brain protein H5; CE5B3 beta; Cell division control-related protein 2; hCDCREL-2; Cerebral protein 7; Peanut-like protein 2
