The C10orf2 Polyclonal Antibody (CAB5303) is a valuable tool for researchers studying the C10orf2 protein, also known as chromatin helicase DNA binding protein 2 (CHD2). This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.C10orf2 is a key player in chromatin remodeling, DNA repair, and transcription regulation processes within the cell. By binding to C10orf2, this antibody allows for precise detection and analysis of the protein in various cell types. Its versatility makes it an ideal choice for studies in genetics, epigenetics, and cancer research.
The role of C10orf2 in maintaining genome stability and gene expression highlights its importance in multiple biological pathways. Research on C10orf2 is essential for understanding its impact on cellular functions and its potential implications in diseases such as cancer, neurological disorders, and developmental abnormalities. By investigating the function of C10orf2, researchers can uncover new insights into genetic mechanisms and potential therapeutic targets for various conditions.
Product Name:
C10orf2 Rabbit Polyclonal Antibody
SKU:
CAB5303
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 135-335 of human C10orf2 (NP_068602.2).
This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
56652
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using C10orf2 antibody (CAB5303) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
