C-Reactive Protein (CRP) Rabbit Polyclonal Antibody (CAB0224)
The C-Reactive Protein Polyclonal Antibody (CAB0224) is an essential tool for researchers studying the role of C-Reactive Protein (CRP) in inflammation and disease. This highly reactive antibody, generated in rabbits, is specifically designed for use in Western blot applications and is validated for its specificity with human samples.CRP is a significant biomarker of inflammation and is commonly used to assess the severity of various conditions, including cardiovascular disease, autoimmune disorders, and infections. The antibody binds to the CRP protein, allowing for the detection and analysis of CRP levels in a variety of samples, making it an invaluable asset for studies in immunology, cardiovascular research, and diagnostics.
By understanding the role of CRP in the inflammatory response, researchers can gain insights into the mechanisms underlying disease progression and develop targeted therapies to combat inflammation-related disorders. The C-Reactive Protein Polyclonal Antibody is a valuable tool that facilitates the investigation of CRP's function and its potential as a therapeutic target.
Product Name:
C-Reactive Protein (CRP) Rabbit Polyclonal Antibody
SKU:
CAB0224
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human C-Reactive Protein (CRP) (NP_000558.2).
The protein encoded by this gene belongs to the pentraxin family which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern recognition molecules, but also complement regulation via recruitment of complement regulators. The encoded protein has a calcium dependent ligand binding domain with a distinctive flattened beta-jellyroll structure. It exists in two forms as either a pentamer in circulation or as a nonsoluble monomer in tissues. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection.
Purification Method:
Affinity purification
Gene ID:
1401
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using C-Reactive Protein (C-Reactive Protein (CRP)) antibody (CAB0224) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
