c-myc Monoclonal Antibody [NYRhc-myc] (CPAB0484)
- SKU:
- CPAB0484
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Universal
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- NYRhc-myc
Frequently bought together:
Description
system_update_alt Datasheet
Product Name: | c-myc Antibody |
Product Sku: | CPAB0484 |
Size: | 500μg |
Host Species: | mouse |
Immunogen: | Synthetic peptides |
Clone: | NYRhc-myc. |
Reactivity: | Other bodies |
Applications: |
Purification Method: | Protein A |
Isotype: | IgG1 |
Background: | c-Myc is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of c-Myc have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. |
Synonyms: | MYC, CMYC, C-MYS, V-MYC, P64. |
Storage Buffer: | Antibody is shipped lyophilized at ambient temperature. |