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c-Jun (Phospho-Ser63) Transcription Factor Activity Assay

SKU:
TFAB00004
Product Type:
ELISA Kit
ELISA Type:
Transcription Factor Assay
Analytes:
c-Jun (Phospho-Ser63)
Reactivity:
Human
Mouse
Rat
$719
Frequently bought together:

Description

system_update_altDatasheet

c-Jun (Phospho-Ser63)Transcription Factor Activity Assay

The c-Jun Phospho-Ser63 Transcription Factor Activity Assay Kit is a highly sensitive and specific assay designed to measure the activity of the transcription factor c-Jun when phosphorylated at serine 63. This kit is suitable for the accurate detection of c-Jun activity in various sample types, including cell lysates and tissue homogenates.c-Jun is a key transcription factor that plays a crucial role in regulating gene expression, cell proliferation, and cell survival. Phosphorylation of c-Jun at serine 63 is known to enhance its transcriptional activity, making it essential for cell growth and differentiation processes.

Dysregulation of c-Jun has been implicated in various diseases, including cancer and inflammatory disorders, highlighting its importance as a potential therapeutic target.With its high sensitivity and reproducibility, the c-Jun Phospho-Ser63 Transcription Factor Activity Assay Kit is an invaluable tool for researchers studying the molecular mechanisms underlying c-Jun signaling and its role in disease pathogenesis. Its user-friendly protocol and reliable results make it ideal for use in a wide range of research applications.

Product Name:c-Jun (Phospho-Ser63) Transcription Factor Activity Assay
Product Code:TFAB00004
Target:c-Jun (Phospho-Ser63)
Synonyms:Activator protein 1, AP1, Proto-oncogene c-Jun, V-jun avian sarcoma virus 17 oncogene homolog, p39
Reactivity:Human, Mouse, Rat
Sample Types:Nuclear or cell lysates

The Assay Genie c-Jun (Phospho-Ser63) transcription factor activity assay allows for the detection and qualitative analysis of c-Jun (Phospho-Ser63) active transcription factors in eukaryotic nuclear or cell lysates.

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:4.5 hours
Detection Method:Colorimetric 450 nm
Size:12 x 8-Well Microstrips
Storage:4°C for 6 months
UniProt Protein Function:Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
NCBI Summary:This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]
UniProt Code:P05412
NCBI GenInfo Identifier:135298
NCBI Gene ID:3725
NCBI Accession:P05412.2
UniProt Secondary Accession:P05412,Q6FHM7, Q96G93,
UniProt Related Accession:P05412
Molecular Weight:
NCBI Full Name:Transcription factor AP-1
NCBI Synonym Full Names:jun proto-oncogene
NCBI Official Symbol:JUN  
NCBI Official Synonym Symbols:AP1; AP-1; c-Jun  
NCBI Protein Information:transcription factor AP-1
UniProt Protein Name:Transcription factor AP-1
UniProt Synonym Protein Names:Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39
Protein Family:C-Jun-amino-terminal kinase-interacting protein
UniProt Gene Name:JUN  
UniProt Entry Name:JUN_HUMAN
AntibodiesELISA Kits
Anti-c-Jun Antibody (CAB0246)Human C-jun (V-Jun Sarcoma Virus 17 Oncogene Homolog) ELISA Kit (HUES01888)
Anti-c-Jun Antibody (CAB11378)c-Jun (Phospho-Ser63) Colorimetric Cell-Based ELISA Kit
Anti-JUN Antibody (CAB16905)c-Jun (Phospho-Ser243) Colorimetric Cell-Based ELISA Kit
Anti-Phospho-Jun-S73 Antibody (CABP0047)c-Jun (Phospho-Thr239) Colorimetric Cell-Based ELISA Kit
Anti-Phospho-Jun-S63 Antibody (CABP0048)c-Jun (Phospho-Thr91) Colorimetric Cell-Based ELISA Kit

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