The C-ABL Monoclonal Antibody (CAB22082) is a valuable tool for researchers studying the ABL gene and its role in various cellular processes. This antibody, produced by Assay Genie, specifically targets the C-ABL protein, a tyrosine kinase involved in cell growth, division, and differentiation.With its high specificity and sensitivity, the CAB22082 antibody is suitable for a range of applications, including Western blotting, immunohistochemistry, and flow cytometry. It has been validated for use with human samples, ensuring reliable and reproducible results in research studies.The C-ABL protein is known to play a critical role in signaling pathways that regulate cell proliferation and survival.
Dysregulation of ABL kinase activity has been implicated in the development of certain cancers, making it a potential target for cancer therapy. By using the CAB22082 antibody, researchers can gain valuable insights into the function of C-ABL and its potential therapeutic implications in cancer research.Overall, the CAB22082 C-ABL Monoclonal Antibody is a valuable tool for scientists investigating the molecular mechanisms underlying cancer development and progression. Its high quality and specificity make it an essential component of any research project aimed at understanding the role of the ABL gene in health and disease.
Product Name:
c-Abl Monoclonal Antibody
SKU:
CAB22082
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1130 of human c-Abl (NP_005148.2).
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.
Purification Method:
Affinity purification
Gene ID:
25
Clone Number:
ARC55104
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of 293F cells, using c-Abl antibody (CAB22082) at1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
