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BUB3 Monoclonal Antibody [PAT2H6AT] (CPAB0617)

SKU:
CPAB0617
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2b
Clone:
PAT2H6AT
Applications:
WB
ELISA
€149

Description

system_update_alt Datasheet

BUB3 Monoclonal Antibody [PAT2H6AT] (CPAB0617)

The Bub3 Polyclonal Antibody (CPAB0617) is a valuable tool for research involving Bub3, a key protein involved in cell cycle regulation and spindle assembly checkpoint signaling. This antibody, produced in rabbits, demonstrates high specificity and sensitivity to human samples, making it an ideal choice for Western blot applications. By targeting the Bub3 protein, this antibody allows for the detection and analysis of Bub3 in various cell types, enabling researchers to study its role in cell division and its implications in cancer and other diseases.Bub3 is essential for proper chromosome segregation during cell division and is crucial for maintaining genomic stability.

Dysregulation of Bub3 has been linked to chromosomal instability and the development of cancer. Therefore, understanding the function of Bub3 is vital for advancing cancer research and developing novel therapies targeting cell cycle defects.Overall, the Bub3 Polyclonal Antibody offers researchers a reliable tool to investigate the role of Bub3 in cell cycle regulation and its potential implications in disease pathology, ultimately contributing to advancements in cancer and biomedical research.

Product Name:BUB3 Antibody
Product Sku:CPAB0617
Size:5μg
Host Species:Mouse
Immunogen:Anti-human BUB3 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human BUB3 protein 1-328 amino acids purified from Ecoli.
Clone:PAT2H6AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:BUB3 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2b
Background:Mitotic checkpoint protein BUB3 (BUB3), is a saved component of the mitotic spindle assembly complex (MCC). The encoded protein has 4 WD repeat domains and has a similar sequence as the yeast BUB3 protein. BUB3 is vital for the kinetochore localization of BUB1 and BUBR1. BUB3 participates in the central spindle checkpoint pathway that operates during early embryogenesis. Furthermore BUB3 has a part in regulating the establishment of correct kinetochore-microtubule attachments.
Synonyms:BUB3L, hBUB3, Mitotic checkpoint protein BUB3.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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