The BTNL2 Polyclonal Antibody (CAB7120) is specifically designed for research involving BTNL2, a cell surface molecule that plays a crucial role in immune regulation and human health. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in various applications, including Western blot analysis. By targeting the BTNL2 protein, this antibody enables the detection and analysis of BTNL2 in different cell types, making it an essential tool for studies in immunology and cancer research.
BTNL2, also known as Butyrophilin-like 2, is a key player in immune response modulation and has been implicated in autoimmune diseases, cancer, and inflammatory conditions. By understanding the function and regulation of BTNL2, researchers can gain valuable insights into disease mechanisms and potential therapeutic targets. The BTNL2 Polyclonal Antibody offers researchers a reliable tool for studying BTNL2 and its role in immune regulation, paving the way for advancements in the field of immunology and human health.
Product Name:
BTNL2 Rabbit Polyclonal Antibody
SKU:
CAB7120
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 246-455 of human BTNL2 (NP_062548.1).
This gene encodes a major histocompatibility complex, class II associated, type I transmembrane protein which belongs to the butyrophilin-like B7 family of immunoregulators. It is thought to be involved in immune surveillance, serving as a negative T-cell regulator by decreasing T-cell proliferation and cytokine release. The encoded protein contains an N-terminal signal peptide, two pairs of immunoglobulin-like domains, separated by a heptad peptide sequence, and a C-terminal transmembrane domain. Naturally occurring mutations in this gene are associated with sarcoidosis, rheumatoid arthritis, ulcerative colitis, inflammatory bowel disease, myositis, type 1 diabetes, systemic lupus erythematosus, acute coronary syndrome, and prostate cancer.
Purification Method:
Affinity purification
Gene ID:
56244
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with BTNL2 using BTNL2 Rabbit pAb (CAB7120) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
