The BTN2A2 Polyclonal Antibody (PACO39502) is a valuable tool for researchers studying BTN2A2, a member of the butyrophilin family of proteins involved in immune regulation. This antibody is raised in rabbits and has been validated for use in Western blot applications, making it an excellent choice for investigating the expression and function of BTN2A2 in various cell types.BTN2A2 has been shown to play a role in immune response modulation, particularly in the regulation of T-cell activation and cytokine production. As such, studies on BTN2A2 are essential for understanding its impact on immune system function and its potential as a therapeutic target in diseases such as cancer, autoimmune disorders, and inflammatory conditions.
By using the BTN2A2 Polyclonal Antibody (PACO39502), researchers can effectively detect and analyze BTN2A2 expression in their experimental samples, providing valuable insights into the role of this protein in immune regulation. This antibody is a valuable tool for researchers working in the fields of immunology and oncology, offering a reliable means of investigating BTN2A2 function in health and disease.
Western blot. All lanes: BTN2A2 antibody at 10µg/ml. Lane 1: MCF-7 whole cell lysate. Lane 2: NIH/3T3 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 60, 38, 29, 46, 36 kDa. Observed band size: 60 kDa.
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO39502 at dilution of 1:100.
Background:
Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.
Synonyms:
Butyrophilin subfamily 2 member A2, BTN2A2, BT2.2 BTF2
UniProt Protein Function:
BTN2A2: Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. Belongs to the immunoglobulin superfamily. BTN/MOG family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 6p22.2Cellular Component: plasma membraneMolecular Function: protein bindingBiological Process: negative regulation of activated T cell proliferation; negative regulation of cellular metabolic process; negative regulation of cytokine secretion
UniProt Protein Details:
NCBI Summary:
Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
