BTN2A2 Antibody (PACO15893)
- SKU:
- PACO15893
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
BTN2A2 Antibody (PACO15893)
The BTN2A2 Polyclonal Antibody (PACO15893) is a key tool for researchers studying BTN2A2, a cell surface protein involved in immune regulation and modulation. This polyclonal antibody, generated in rabbits, offers high specificity and reactivity with human samples, making it a valuable resource for Western blot applications. By binding to the BTN2A2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for studies in immunology and cancer research.
BTN2A2, also known as immune checkpoint protein, plays a crucial role in immune response modulation by regulating T cell activation and cytokine release. Its significance in immune homeostasis makes it a promising target for research into diseases such as cancer, infectious diseases, and autoimmune disorders. Understanding the function of BTN2A2 is vital for developing targeted therapies that manipulate immune responses in these conditions, offering new possibilities for treatment and management.
| Antibody Name: | BTN2A2 Antibody (PACO15893) |
| Antibody SKU: | PACO15893 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human BTN2A2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15893(BTN2A2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid, and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Synonyms: | butyrophilin, subfamily 2, member A2 |
| UniProt Protein Function: | BTN2A2: Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. Belongs to the immunoglobulin superfamily. BTN/MOG family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 6p22.2Cellular Component: plasma membraneMolecular Function: protein bindingBiological Process: negative regulation of activated T cell proliferation; negative regulation of cellular metabolic process; negative regulation of cytokine secretion |
| UniProt Protein Details: | |
| NCBI Summary: | Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] |
| UniProt Code: | Q8WVV5 |
| NCBI GenInfo Identifier: | 308522746 |
| NCBI Gene ID: | 10385 |
| NCBI Accession: | NP_001184166.1 |
| UniProt Secondary Accession: | Q8WVV5,O00480, A6NM84, B4DE97, B4DQ01, E9PH07 |
| UniProt Related Accession: | Q8WVV5 |
| Molecular Weight: | 41.7kD |
| NCBI Full Name: | butyrophilin subfamily 2 member A2 isoform a |
| NCBI Synonym Full Names: | butyrophilin subfamily 2 member A2 |
| NCBI Official Symbol: | BTN2A2Â Â |
| NCBI Official Synonym Symbols: | BTF2; BT2.2; BTN2.2Â Â |
| NCBI Protein Information: | butyrophilin subfamily 2 member A2 |
| UniProt Protein Name: | Butyrophilin subfamily 2 member A2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Butyrophilin subfamily |
| UniProt Gene Name: | BTN2A2Â Â |
| UniProt Entry Name: |
| Antibodies |
| BTN2A2 Antibody (PACO08061) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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