BTN2A2 Antibody (PACO15892)
- SKU:
- PACO15892
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
BTN2A2 Antibody (PACO15892)
The BTN2A2 Polyclonal Antibody (PACO15892) is a vital tool for research involving BTN2A2, a cell surface protein known for its role in immune regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the BTN2A2 protein, this antibody allows for the detection and analysis of BTN2A2 in various cell types, making it ideal for studies in immunology and cancer research.BTN2A2 is recognized for its involvement in immune response modulation, particularly in regulating inflammation and inhibiting allergic reactions.
Its significance in maintaining immune homeostasis positions BTN2A2 as a valuable target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of BTN2A2 is essential for the development of therapies that manipulate immune function in these disease contexts.
| Antibody Name: | BTN2A2 Antibody (PACO15892) |
| Antibody SKU: | PACO15892 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human BTN2A2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15892(BTN2A2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid, and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Synonyms: | butyrophilin, subfamily 2, member A2 |
| UniProt Protein Function: | BTN2A2: Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. Belongs to the immunoglobulin superfamily. BTN/MOG family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 6p22.2Cellular Component: plasma membraneMolecular Function: protein bindingBiological Process: negative regulation of activated T cell proliferation; negative regulation of cellular metabolic process; negative regulation of cytokine secretion |
| UniProt Protein Details: | |
| NCBI Summary: | Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] |
| UniProt Code: | Q8WVV5 |
| NCBI GenInfo Identifier: | 308522746 |
| NCBI Gene ID: | 10385 |
| NCBI Accession: | NP_001184166.1 |
| UniProt Secondary Accession: | Q8WVV5,O00480, A6NM84, B4DE97, B4DQ01, E9PH07 |
| UniProt Related Accession: | Q8WVV5 |
| Molecular Weight: | 41.7kD |
| NCBI Full Name: | butyrophilin subfamily 2 member A2 isoform a |
| NCBI Synonym Full Names: | butyrophilin subfamily 2 member A2 |
| NCBI Official Symbol: | BTN2A2Â Â |
| NCBI Official Synonym Symbols: | BTF2; BT2.2; BTN2.2Â Â |
| NCBI Protein Information: | butyrophilin subfamily 2 member A2 |
| UniProt Protein Name: | Butyrophilin subfamily 2 member A2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Butyrophilin subfamily |
| UniProt Gene Name: | BTN2A2Â Â |
| UniProt Entry Name: |
| Antibodies |
| BTN2A2 Antibody (PACO08061) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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