The BTK Polyclonal Antibody is a valuable tool for researchers studying the protein Bruton's tyrosine kinase (BTK), a key player in B-cell signaling and development. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting BTK in human samples, making it suitable for Western blot applications.BTK is a crucial enzyme involved in B-cell receptor signaling, and its dysregulation has been implicated in various B-cell malignancies and autoimmune diseases. By targeting BTK with this antibody, researchers can gain insights into the role of this protein in normal and disease states, advancing our understanding of B-cell biology and potentially identifying therapeutic targets for BTK-related disorders.
With its ability to specifically recognize and bind to BTK, the BTK Polyclonal Antibody offers a reliable tool for investigating the function and regulation of this important protein in both basic and translational research. Its versatility and reliability make it an essential reagent for studies focusing on B-cell biology, immunology, and related diseases.
Product Name:
BTK Polyclonal Antibody
SKU:
CAB21618
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 173-272 of human BTK (NP_000052.1).
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
695
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using BTK Rabbit pAb (CAB21618) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
